Latent Classes of Cognitive and Functional Trajectories in AD 

 
   Lead Investigator:    Jeannie-Marie Leoutsakos
   Institution      :    Johns Hopkins School of Medicine
   E-Mail           :    jeannie-marie@jhu.edu
   Proposal ID      :    420


   Publications:


1  Forrester SN, Gallo JJ, Smith GS, Leoutsakos JS
   Patterns of Neuropsychiatric Symptoms in Mild Cognitive Impairment and Risk of Dementia
   Journal Article  Am J Geriatr Psychiatry,24:117-125,2016,PMC4646727

   PUBLISHED





   Proposal Description:
   We will use parallel-process growth mixture modelling to jointly model latent classes of trajectories of MMSE and CDR in incident NACC AD cases.  We will then model baseline predictors of latent trajectory class membership, including baseline cognitive test scores, age, sex, race, NPI domain scores, cardiovascular risk factors, other medical comorbidities, and concomitant medications.